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Tg(CMV-Msx2*P7H)1Rem
Transgene Detail
Nomenclature
Symbol: Tg(CMV-Msx2*P7H)1Rem
Name: transgene insertion 1, Robert E Maxson
MGI ID: MGI:3762251
Synonyms: CMV-Msx2-Pro7His
Transgene: Tg(CMV-Msx2*P7H)1Rem  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CMV-Msx2*P7H)1Rem expresses 1 gene
 
Mutation detailsThis transgene consists of a 1.1-kb fragment of the mouse Msx2 gene containing 0.3 kb of the 3.5-kb intron and a PCR-mutagenized version of the second exon bearing the Pro7His mutation under the control of human cytomegalovirus (CMV) promoter. This single base pair mutation is seen in individuals affected with Boston-type craniosynostosis. (J:26513)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:26513 Liu YH, et al., Premature suture closure and ectopic cranial bone in mice expressing Msx2 transgenes in the developing skull. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6137-41
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory