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Targeted Allele Detail
Symbol: Psmd4tm2.1Smta
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; targeted mutation 2.1, Shigeo Murata
MGI ID: MGI:3762171
Synonyms: Rpn10deltaUIM
Gene: Psmd4  Location: Chr3:95032694-95042614 bp, - strand  Genetic Position: Chr3, 40.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:126546
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre-mediated recombination was used to remove the floxed fragment containing a cDNA that encodes amino acids 219 to 376 and a neo cassette leaving behind a modified exon 7 with a stop codon and polyadenylation site. This removed the UIM domains from the protein. PCR genotyping was used to confirm the removal of the cDNA fragment and neo cassette. (J:126546)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psmd4 Mutation:  18 strains or lines available
Original:  J:126546 Hamazaki J, et al., Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development. Mol Cell Biol. 2007 Oct;27(19):6629-38
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
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