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Tg(KLK3-cre)D4Trp
Transgene Detail
Nomenclature
Symbol: Tg(KLK3-cre)D4Trp
Name: transgene insertion D4, Jan Trapman
MGI ID: MGI:3761848
Synonyms: PSA-cre, PSA-creD4
Transgene: Tg(KLK3-cre)D4Trp  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe construct uses the human prostate-specific antigen promoter (referred to as PSA; proper designation KLK3) to drive transcription of the cre recombinase cDNA. The transgene was injected into fertilized FVB oocytes. Prostate-specific expression was verified by crossing to Tg(ACTB-cat,-lacZ)34Pva transgenic mice. Founder line D4 showed high, prostate-specific cre activity. (J:99524)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: KLK3     Summary of all recombinase alleles driven by KLK3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:99524 Ma X, et al., Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res. 2005 Jul 1;65(13):5730-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory