Kcnj10^tm1Kdmc
Targeted Allele Detail

Summary

• Symbol: Kcnj10^tm1Kdmc
• Name: potassium inwardly-rectifying channel, subfamily J, member 10; targeted mutation 1, Ken D McCarthy
• MGI ID: MGI:3761690
• Synonyms: Kir4.1^f
• Gene: Kcnj10 Location: Chr1:172168777-172201652 bp, + strand Genetic Position: Chr1, 79.69 cM
• Alliance: Kcnj10^tm1Kdmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126082
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of an exon encoding the entire reading frame and a frt-flanked neo cassette was inserted downstream of the exon. The neo cassette was removed by Flp-recombinase activity following a cross to Tg(ACTFLPe)9205Dym mice. (J:126082)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnj10 Mutation: 25 strains or lines available

References

• Original: J:126082 Djukic B, et al., Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation. J Neurosci. 2007 Oct 17;27(42):11354-65
• All: 18 reference(s)