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Transgene Detail
Symbol: Tg(Tcra5CC7,Tcrb5CC7)IWep
Name: transgene insertion I, William E Paul
MGI ID: MGI:3761187
Synonyms: 5C.C7, 5CC7 TCR, 5cc7 TCR-Tg, Cyt5CC7, TCR-Cyt-5CC7-I, [Tg]TCRCyt5CC7-I
Transgene: Tg(Tcra5CC7,Tcrb5CC7)IWep  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Tcra5CC7,Tcrb5CC7)IWep expresses 2 genes
Mutation detailsRearranged mouse alpha and beta TCR were derived from DNA of the 5C.C7 T cell clone which originated from mice immunized with pigeon cytochrome c. The Tcr Valpha11.1 JalphaC7 construct lacks the 3' alpha enhancer and the Tcr Vbeta3 Dbeta1.1 Jbeta1.2 construct includes the endogenous 3' beta-chain enhancer. The transgene is expressed in more than 95% of all CD4+ cells on the original B10.BR background. (J:111186)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:124386 Seder RA, et al., The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med. 1992 Oct 1;176(4):1091-8
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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