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Ramp1tm1.1Tsuj
Targeted Allele Detail
Nomenclature
Symbol: Ramp1tm1.1Tsuj
Name: receptor (calcitonin) activity modifying protein 1; targeted mutation 1, Kazutake Tsujikawa
MGI ID: MGI:3761144
Gene: Ramp1  Location: Chr1:91179822-91225196 bp, + strand  Genetic Position: Chr1, 46.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125974
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated by breeding mice heterozygous for Ramp1tm1Tsuj with transgenic mice ubiquitously expressing cre recombinase. Exon 2 of the gene and the neomycin resistance cassette were removed, leaving behind a single loxP site. Upon deletion of exon 2, the splicing of exons 1 to 3 created a frameshift that resulted in the introduction of a termination codon at the beginning of exon 3. RT-PCR analysis of the thymus indicated there was no transcription of the wild-type gene. (J:125974)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ramp1 Mutation:  13 strains or lines available
References
Original:  J:125974 Tsujikawa K, et al., Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16702-7
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory