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Foxn1tm3(cre)Nrm
Targeted Allele Detail
Nomenclature
Symbol: Foxn1tm3(cre)Nrm
Name: forkhead box N1; targeted mutation 3, Nancy R Manley
MGI ID: MGI:3760775
Synonyms: Foxn1ex9cre
Gene: Foxn1  Location: Chr11:78248403-78277384 bp, - strand  Genetic Position: Chr11, 46.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125817
Parent Cell Line:  LK-1/LK1 (ES Cell)
Strain of Origin:  C57BL/6NHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsAn IRES-cre and floxed or frt neo cassette were inserted into the 3' end of exon 9. Insertion was confirmed by PCR of genomic DNA. Removal of the neo cassette by frt-mediated recombination following a cross with Tg(ACTFLPe)9205Dym mice results in a loss of ectopic cre expression but specific expression is retained. RT-PCR was used to confirm that endogenous gene expression was unaffected. (J:125817)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxn1     Summary of all recombinase alleles driven by Foxn1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Foxn1 Mutation:  88 strains or lines available
References
Original:  J:125817 Gordon J, et al., Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus. BMC Dev Biol. 2007;7:69
All:  55 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory