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TesGt(RRH061)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: TesGt(RRH061)Byg
Name: testin LIM domain protein; gene trap RRH061, BayGenomics
MGI ID: MGI:3760502
Synonyms: TesGT
Gene: Tes  Location: Chr6:17065148-17105824 bp, + strand  Genetic Position: Chr6, 7.67 cM
Mutation
origin
Mutant Cell Line:  RRH061
Germline Transmission:  Earliest citation of germline transmission: J:125765
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     Vector Type: gene trap
 
Mutation detailsThe gene trap vector was inserted between exons 3 and 4 disrupting the PET and LIM domains. The absence of a protein product was confirmed by western blot analysis on protein extracts from E10.5 embryos. These allele produces a fusion protein containing 133 amino acids fused to the beta-geo cassette. Since only 32 amino acids of the 104 amino acid PET domain are present in the fusion product this allele is expected to be a null allele. (J:125765)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 90 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tes Mutation:  17 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:125765 Crompton LA, et al., Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues. Dev Dyn. 2007 Nov;236(11):3137-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory