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Transgene Detail
Symbol: Tg(CD74)AR194Ayr
Name: transgene insertion AR194, Alexander Y Rudensky
MGI ID: MGI:3760406
Synonyms: hIi, hIiWT
Transgene: Tg(CD74)AR194Ayr  Location: unknown  
Strain of Origin:  (C57BL/6J x DBA/2J)F1 x C57BL/6J
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(CD74)AR194Ayr expresses 1 gene
Mutation detailsA vector containing the human class II-associated invariant chain gene (hIi, CD74) and promoter was injected into (C57BL/6J x DBA/2J)F1 x C57BL/6J embryos. This line (AR194) was initially backcrossed to C57BL/6-congenic invariant chain targeted mutant mice and later crossed with inbred C57BL/6 animals for a total of more than 12 generations by the donating investigator. This line no longer carries the invariant chain targeted mutation. (J:88717)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:88717 Honey K, et al., Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M. J Immunol. 2004 Apr 1;172(7):4142-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory