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Actn3tm1Knno
Targeted Allele Detail
Nomenclature
Symbol: Actn3tm1Knno
Name: actinin alpha 3; targeted mutation 1, Kathryn N North
MGI ID: MGI:3760255
Synonyms: Actn3-
Gene: Actn3  Location: Chr19:4861223-4877909 bp, - strand  Genetic Position: Chr19, 4.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125639
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 7 were replace with a neo cassette. The absence of protein product was confirmed by western blot analysis. (J:125639)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Actn3 Mutation:  23 strains or lines available
References
Original:  J:125639 Macarthur DG, et al., Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nat Genet. 2007 Oct;39(10):1261-5
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory