About   Help   FAQ
Actn3tm1Knno
Targeted Allele Detail
Nomenclature
Symbol: Actn3tm1Knno
Name: actinin alpha 3; targeted mutation 1, Kathryn N North
MGI ID: MGI:3760255
Synonyms: Actn3-
Gene: Actn3  Location: Chr19:4861223-4877909 bp, - strand  Genetic Position: Chr19, 4.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125639
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 7 were replace with a neo cassette. The absence of protein product was confirmed by western blot analysis. (J:125639)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Actn3 Mutation:  26 strains or lines available
References
Original:  J:125639 Macarthur DG, et al., Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nat Genet. 2007 Oct;39(10):1261-5
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/12/2017
MGI 6.10
The Jackson Laboratory