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Targeted Allele Detail
Symbol: Magel2tm1Stw
Name: melanoma antigen, family L, 2; targeted mutation 1, Colin L Stewart
MGI ID: MGI:3760092
Synonyms: Magel2-
Gene: Magel2  Location: Chr7:62377010-62381640 bp, + strand  Genetic Position: Chr7, 34.37 cM
Older Magel2tm1Stw/Magel2+ females that inherit the mutant allele paternally lack corpora lutea in the ovaries

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:125637
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire open reading frame was replaced with a lacZ-neo cassette. The endogenous promoter drives the expression of lacZ as confirmed by a beta-galactosidase assay. The absence of the paternal transcript was confirmed by RT-PCR. (J:125637)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Magel2 Mutation:  25 strains or lines available
Original:  J:125637 Kozlov SV, et al., The imprinted gene Magel2 regulates normal circadian output. Nat Genet. 2007 Oct;39(10):1266-72
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory