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Chn1mfy
Spontaneous Allele Detail
Nomenclature
Symbol: Chn1mfy
Name: chimerin 1; miffy
MGI ID: MGI:3760001
Synonyms: alpha-Chnmfy, mfy
Gene: Chn1  Location: Chr2:73610660-73775346 bp, - strand  Genetic Position: Chr2, 43.78 cM
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Spontaneous
Mutation:    Transposon insertion
 
Mutation detailsA retroposon insertion into exon 9 resulted in deletion of exon 9 (174 bp) in the alpha1 and alpha2 transcripts, and deletion of four nucleotides (including the putative initiation codon) and failure of intron 9 splicing in the alpha3 transcript. Partial rescue of the locomotor phenotype with an alpha-chimerin Tg was used as evidenct that Chn was the causal gene of the mutation. (J:125703)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Chn1 Mutation:  22 strains or lines available
Notes
Genbank sequences for this mutation: AB264771, AB264772, and AB264773
References
Original:  J:125703 Iwasato T, et al., Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell. 2007 Aug 24;130(4):742-53
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory