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Targeted Allele Detail
Symbol: F10tm2Ccmt
Name: coagulation factor X; targeted mutation 2, Katherine A High
MGI ID: MGI:3760000
Synonyms: F10-Friuli
Gene: F10  Location: Chr8:13037308-13056676 bp, + strand  Genetic Position: Chr8, 5.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:145092
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 8 contains the missense mutation encoding Factor X Friuli (Pro343Ser). This allele was generated by targeting the "socket" F10tm1Ccmt allele with a "plug" that introduced the Friuli mutation and simultaneously eliminated the neomycin resistance gene and reconstituted the Hprt gene, allowing selection of correctly targeted ES cells for HAT resistance and G418 sensitivity. Extrinsic and intrinsic protein activity is decreased to 5% of wild-type. (J:145092)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F10 Mutation:  12 strains or lines available
Original:  J:145092 Tai SJ, et al., A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X. J Thromb Haemost. 2008 Feb;6(2):339-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
The Jackson Laboratory