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Itgavtm2.1Hyn
Targeted Allele Detail
Nomenclature
Symbol: Itgavtm2.1Hyn
Name: integrin alpha V; targeted mutation 2.1, Richard Hynes
MGI ID: MGI:3759837
Synonyms: alphav-
Gene: Itgav  Location: Chr2:83724397-83806916 bp, + strand  Genetic Position: Chr2, 49.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94376
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 4 was removed by cre-mediated recombination to create a null allele. Absence of protein expression was confirmed by FACS analysis of macrophages and splenocytes. (J:94376, J:125508)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgav Mutation:  8 strains or lines available
References
Original:  J:94376 McCarty JH, et al., Selective ablation of {alpha}v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan;132(1):165-176
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory