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Targeted Allele Detail
Symbol: Itgavtm2Hyn
Name: integrin alpha V; targeted mutation 2, Richard Hynes
MGI ID: MGI:3759836
Synonyms: alphavflox
Gene: Itgav  Location: Chr2:83724397-83806916 bp, + strand  Genetic Position: Chr2, 49.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:94376
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted at the 5' start of exon 4 and additional loxP site was inserted downstream of exon 4 to create a floxed allele. The neo cassette was removed by cre-mediated recombination (source not specified). Insertion was confirmed by PCR and Southern blot. (J:94376, J:125508)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Itgav Mutation:  9 strains or lines available
Original:  J:94376 McCarty JH, et al., Selective ablation of {alpha}v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan;132(1):165-176
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory