Gnao1^tm2Adhi
Targeted Allele Detail

Summary

• Symbol: Gnao1^tm2Adhi
• Name: guanine nucleotide binding protein, alpha O; targeted mutation 2, Anurdha Dhingra
• MGI ID: MGI:3759769
• Synonyms: Galphao2, Go2alpha
• Gene: Gnao1 Location: Chr8:94536781-94696016 bp, + strand Genetic Position: Chr8, 45.94 cM
• Alliance: Gnao1^tm2Adhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125588
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Cys-255 in exon 7.2 was replaced with a stop codon and a neo cassette was added at the end of the genomic sequence. Expression of a protein product of 40 kDa, with a minor 50 kDa band, was confirmed by western blot on retinal extracts. (J:125588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnao1 Mutation: 29 strains or lines available

References

• Original: J:125588 Dhingra A, et al., Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o). J Neurosci. 2002 Jun 15;22(12):4878-84
• All: 3 reference(s)