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Gnao1tm2Adhi
Targeted Allele Detail
Nomenclature
Symbol: Gnao1tm2Adhi
Name: guanine nucleotide binding protein, alpha O; targeted mutation 2, Anurdha Dhingra
MGI ID: MGI:3759769
Synonyms: Galphao2, Go2alpha
Gene: Gnao1  Location: Chr8:93810561-93969388 bp, + strand  Genetic Position: Chr8, 45.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125588
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Nucleotide substitutions
 
Mutation detailsCys-255 in exon 7.2 was replaced with a stop codon and a neo cassette was added at the end of the genomic sequence. Expression of a protein product of 40 kDa, with a minor 50 kDa band, was confirmed by western blot on retinal extracts. (J:125588)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnao1 Mutation:  4 strains or lines available
References
Original:  J:125588 Dhingra A, et al., Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o). J Neurosci. 2002 Jun 15;22(12):4878-84
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory