Ppp2r3c^tm1Imku
Targeted Allele Detail

Summary

• Symbol: Ppp2r3c^tm1Imku
• Name: protein phosphatase 2, regulatory subunit B'', gamma; targeted mutation 1, Nobuo Sakaguchi
• MGI ID: MGI:3759678
• Synonyms: G5pr^F
• Gene: Ppp2r3c Location: Chr12:55327594-55350024 bp, - strand Genetic Position: Chr12, 23.9 cM, cytoband C1
• Alliance: Ppp2r3c^tm1Imku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100706
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette downstream of exon 2. Insertion was confirmed by Southern blot analysis. Cre-mediated recombination can remove the first 2 exons and result in an absence of transcript, as confirmed by RT-PCR. (J:100706)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2r3c Mutation: 41 strains or lines available

References

• Original: J:100706 Xing Y, et al., Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. J Exp Med. 2005 Sep 5;202(5):707-19
• All: 2 reference(s)