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Ppp2r3ctm1Imku
Targeted Allele Detail
Nomenclature
Symbol: Ppp2r3ctm1Imku
Name: protein phosphatase 2, regulatory subunit B'', gamma; targeted mutation 1, Nobuo Sakaguchi
MGI ID: MGI:3759678
Synonyms: G5prF
Gene: Ppp2r3c  Location: Chr12:55280814-55303000 bp, - strand  Genetic Position: Chr12, 23.9 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100706
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a floxed neo cassette downstream of exon 2. Insertion was confirmed by Southern blot analysis. Cre-mediated recombination can remove the first 2 exons and result in an absence of transcript, as confirmed by RT-PCR. (J:100706)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp2r3c Mutation:  22 strains or lines available
References
Original:  J:100706 Xing Y, et al., Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. J Exp Med. 2005 Sep 5;202(5):707-19
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory