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SufuGt(XB699)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: SufuGt(XB699)Byg
Name: SUFU negative regulator of hedgehog signaling; gene trap XB699, BayGenomics
MGI ID: MGI:3759455
Synonyms: Sufu-
Gene: Sufu  Location: Chr19:46396896-46488804 bp, + strand  Genetic Position: Chr19, 38.85 cM
Mutation
origin
Mutant Cell Line:  XB699
Germline Transmission:  Earliest citation of germline transmission: J:125534
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Hypomorph)
Mutation:    Insertion of gene trap vector     Vector: pGT0pfs     Vector Type: gene trap
 
Mutation detailsA beta-geo cassette was inserted into the last exon and 3'UTR to create a truncation in which nucleotides 1482-1639 are missing. The truncated protein lacks the GLI-interating region. LacZ staining was used to confirm the insertion of the gene trap vector. (J:125534)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sufu Mutation:  18 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:125534 Lee Y, et al., Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene. 2007 Sep 27;26(44):6442-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory