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B3gat1tm1Tkaw
Targeted Allele Detail
Nomenclature
Symbol: B3gat1tm1Tkaw
Name: beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P); targeted mutation 1, Toshisuke Kawasaki
MGI ID: MGI:3759445
Synonyms: GlcAT-P-
Gene: B3gat1  Location: Chr9:26733728-26763101 bp, + strand  Genetic Position: Chr9, 11.49 cM, cytoband A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125254
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 and 5 were replaced with a neo cassette disrupting domains critical for glucoronyltransferasse activity to create a null allele. The absence of transcript was confirmed by a northern blot using mRNA extracted from the brains of 10 week old mice. (J:125254)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any B3gat1 Mutation:  10 strains or lines available
References
Original:  J:125254 Yamamoto S, et al., Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning. J Biol Chem. 2002 Jul 26;277(30):27227-31
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory