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Cln3tm1Blda
Targeted Allele Detail
Nomenclature
Symbol: Cln3tm1Blda
Name: ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease); targeted mutation 1, Beverly L Davidson
MGI ID: MGI:3759415
Synonyms: Cln3lacZ
Gene: Cln3  Location: Chr7:126571400-126585817 bp, - strand  Genetic Position: Chr7, 69.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125194
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsGenomic sequence from the ATG in exon 1 through exons 8 was replaced with a beta-gal-pA and TKPneo cassette then knocked into the open reading frame to produce a null reporter allele. Expression of the lacZ was confirmed by X-gal assay and the absence of a transcript was confirmed RT-PCR. (J:125194)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cln3 Mutation:  11 strains or lines available
References
Original:  J:125194 Eliason SL, et al., A knock-in reporter model of Batten disease. J Neurosci. 2007 Sep 12;27(37):9826-34
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory