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Tg(Prnp-SNCA*)1Mgsp
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-SNCA*)1Mgsp
Name: transgene insertion 1, Maria Grazia Spillantini
MGI ID: MGI:3758656
Transgene: Tg(Prnp-SNCA*)1Mgsp  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-SNCA*)1Mgsp expresses 1 gene
 
Mutation detailsThe construct consisted of the sequence expressing human alpha-synuclein 1-120 which is truncated, lacking the final 20 amino acids inserted downstream of the mouse prion protein promoter. These mice were crossed to C57BL/6JOlaHsd mice which lack alpha-synuclein as a result of a spontaneous deletion of the alpha-SNCA locus. Transgenic expression of the truncated protein is more widespread in the substantia nigra and striatum than that observed in mice with the same transgene expressed by the tyrosine hydroxylase promoter. (J:108310, J:125212)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:125212 Michell AW, et al., The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease. Cell Transplant. 2007;16(5):461-74
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory