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Transgene Detail
Symbol: Tg(Camk2a-DISC1)10Asaw
Name: transgene insertion 10, Akira Sawa
MGI ID: MGI:3758077
Synonyms: DN_DISC1, DN-DISC1
Transgene: Tg(Camk2a-DISC1)10Asaw  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Camk2a-DISC1)10Asaw expresses 1 gene
Mutation detailsThe Camk2a promoter drives the expression of a truncated human DISC1 open reading frame that produces amino acids 1 through 597. This truncated protein is thought to function as a dominant negative. The transgene is expressed preferentially in neonatal stages, especially in pyramidal neurons of the dentate gyrus, and does not interfere with endogenous gene expression from Disc1. This is the low expressing line. (J:124683)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Two lines were created (lines 10 and 37) that display similar phenotypes.

Original:  J:124683 Hikida T, et al., From the Cover: Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14501-6
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory