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Targeted Allele Detail
Symbol: Dbx1tm1(DTA)Apie
Name: developing brain homeobox 1; targeted mutation 1, Alessandra Pierani
MGI ID: MGI:3757953
Synonyms: Dbx1DTA, Dbx1IRES-loxP-Stop-loxP-DTA, Dbx1loxP-stop-loxP-DTA
Gene: Dbx1  Location: Chr7:49631499-49636835 bp, - strand  Genetic Position: Chr7, 31.44 cM
Germline Transmission:  Earliest citation of germline transmission: J:101434
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsAn IRES floxed PGK-neo cassette and the diphtheria toxin (DTA) gene were inserted in the downstream untranslated portion of the gene. Multiple stop codons in the PGK-neo cassette prevent translation read-through of the diphtheria toxin gene. Functional DTA is expressed upon Cre-mediated recombination. (J:101434)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dbx1 Mutation:  12 strains or lines available
Original:  J:101434 Bielle F, et al., Multiple origins of Cajal-Retzius cells at the borders of the developing pallium. Nat Neurosci. 2005 Aug;8(8):1002-12
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory