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Tg(Myh6-tTA)55Rbns
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-tTA)55Rbns
Name: transgene insertion 55, Jeffrey Robbins
MGI ID: MGI:3757936
Synonyms: alpha-MHC-tTA
Transgene: Tg(Myh6-tTA)55Rbns  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of the tetracycline transactivator (a chimeric tTA fusion protein of the Tn10 Tet resistance operon in E.coli and the carboxy-terminal portion of the transactivator protein from herpes simplex virus -VP16) under the control of thecardiac specific mouse alpha myosin heavy chain. Although transgene protein expression is not detected in the heart via Western blot, when transgenics are crossed with Tg(tetop-lacZ)2Mam, uniform and robust expression of lacZ is seen in the hearts, indicating that very low levels of tTA protein are present to induce lacZ expression. (J:125131)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:125131 Sanbe A, et al., Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res. 2003 Apr 4;92(6):609-16
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory