Ppargc1b^tm1.1Avp
Targeted Allele Detail

Summary

• Symbol: Ppargc1b^tm1.1Avp
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta; targeted mutation 1.1, Antonio Vidal-Pulg
• MGI ID: MGI:3757705
• Synonyms: PGC-1B
• Gene: Ppargc1b Location: Chr18:61431207-61533502 bp, - strand Genetic Position: Chr18, 34.41 cM
• Alliance: Ppargc1b^tm1.1Avp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116167
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 4 and 5 were removed using cre-mediated recombination. The resulting decrease in the size of the coding region was confirmed by PCR. Deletion of exon 4 and 5 was further confirmed by RT-PCR. (J:116167)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppargc1b Mutation: 56 strains or lines available

References

• Original: J:116167 Lelliott CJ, et al., Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol. 2006 Nov;4(11):e369
• All: 10 reference(s)