Rr158^tm1(Igh)Xu
Targeted Allele Detail

Summary

• Symbol: Rr158^tm1(Igh)Xu
• Name: regulatory region 158; targeted mutation 1, Yang Xu
• MGI ID: MGI:3757685
• Synonyms: EmuR, Igk-Eik^tm1(Igh)Xu
• Gene: Rr158 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr158^tm1(Igh)Xu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124407
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The light chain intronic enhancer Ekappa, located between Igkj and Igkc gene segment clusters, was replaced with 0.8 kb XbaI fragment of the Igh locus that spans the entire heavy chain intronic enchancer element (Emu or Rr150) and flanking matrix attachment regions. A floxed neomycin selection cassette was included downstream. The neomycin selection cassette was removed by transient Cre recombinase expression. (J:124407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr158 Mutation: 0 strains or lines available

References

• Original: J:124407 Inlay MA, et al., Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci. J Exp Med. 2006 Jul 10;203(7):1721-32
• All: 2 reference(s)