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Gclmtm1Tjka
Targeted Allele Detail
Nomenclature
Symbol: Gclmtm1Tjka
Name: glutamate-cysteine ligase, modifier subunit; targeted mutation 1, Terrance J Kavanagh
MGI ID: MGI:3723647
Synonyms: Gclm(-)
Gene: Gclm  Location: Chr3:122245487-122267215 bp, + strand  Genetic Position: Chr3, 52.94 cM, cytoband H1-3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129361
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced by a promotorless beta-geo cassette. Absence of a protein product was confirmed by western blot using liver and kidney tissue. (J:125009)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gclm Mutation:  3 strains or lines available
References
Original:  J:129361 Giordano G, et al., Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency. Mol Pharmacol. 2006 Dec;70(6):2116-26
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory