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Kcnn4tm1Rklr
Targeted Allele Detail
Nomenclature
Symbol: Kcnn4tm1Rklr
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; targeted mutation 1, Ralf Kohler
MGI ID: MGI:3722942
Synonyms: Kca3.1-
Gene: Kcnn4  Location: Chr7:24370263-24386690 bp, + strand  Genetic Position: Chr7, 10.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124858
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to insert a neomycin resistance cassette into the locus to replace exon 4. Absence of protein was confirmed by Western blot analysis. (J:124858)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnn4 Mutation:  7 strains or lines available
References
Original:  J:124858 Si H, et al., Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+ channel. Circ Res. 2006 Sep 1;99(5):537-44
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory