Kcnn4^tm1Rklr
Targeted Allele Detail

Summary

• Symbol: Kcnn4^tm1Rklr
• Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; targeted mutation 1, Ralf Kohler
• MGI ID: MGI:3722942
• Synonyms: Kca3.1^-
• Gene: Kcnn4 Location: Chr7:24069750-24084635 bp, + strand Genetic Position: Chr7, 10.37 cM
• Alliance: Kcnn4^tm1Rklr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124858
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a neomycin resistance cassette into the locus to replace exon 4. Absence of protein was confirmed by Western blot analysis. (J:124858)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnn4 Mutation: 18 strains or lines available

References

• Original: J:124858 Si H, et al., Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+ channel. Circ Res. 2006 Sep 1;99(5):537-44
• All: 13 reference(s)