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Pds5btm1Jmi
Targeted Allele Detail
Nomenclature
Symbol: Pds5btm1Jmi
Name: PDS5 cohesin associated factor B; targeted mutation 1, Jeffrey Milbrandt
MGI ID: MGI:3722688
Synonyms: Psd5b-
Gene: Pds5b  Location: Chr5:150673739-150810690 bp, + strand  Genetic Position: Chr5, 89.61 cM
Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg Pds5btm1Jmi/Pds5b+ and Pds5aGt(RRM243)Byg/Pds5a+ Pds5btm1Jmi/Pds5btm1Jmi mice display abnormal lens development

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124279
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding region of the second exon is replaced by a betagal/pgk-neo cassette. The floxed neo was removed via cre mediated recombination. Protein was not detected in mutants by immunoblot analysis. (J:124279)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 26 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pds5b Mutation:  28 strains or lines available
References
Original:  J:124279 Zhang B, et al., Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development. 2007 Sep;134(17):3191-201
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory