Htr7^tm1Wtkn
Targeted Allele Detail

Summary

• Symbol: Htr7^tm1Wtkn
• Name: 5-hydroxytryptamine (serotonin) receptor 7; targeted mutation 1, Jeffrey M Witkin
• MGI ID: MGI:3722446
• Synonyms: 5-HT7^-
• Gene: Htr7 Location: Chr19:35936134-36034907 bp, - strand Genetic Position: Chr19, 30.3 cM
• Alliance: Htr7^tm1Wtkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124549
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence in exon 1 containing amino acid residues 5-138 was replaced with a neomycin resistance cassette. (J:124549)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr7 Mutation: 32 strains or lines available

References

• Original: J:124549 Witkin JM, et al., Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds. Epilepsy Res. 2007 Jun;75(1):39-45
• All: 2 reference(s)