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Nlrc4tm1Gln
Targeted Allele Detail
Nomenclature
Symbol: Nlrc4tm1Gln
Name: NLR family, CARD domain containing 4; targeted mutation 1, Jorge E Galan
MGI ID: MGI:3722152
Synonyms: ipaf-
Gene: Nlrc4  Location: Chr17:74426295-74459108 bp, - strand  Genetic Position: Chr17, 45.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124378
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector inserted the IRES/nls-lacZ/MC1neo cassette to replace exons 2 and 3. RT-PCR confirmed absence of transcript in mutants. (J:124378)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrc4 Mutation:  33 strains or lines available
References
Original:  J:124378 Lara-Tejero M, et al., Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med. 2006 Jun 12;203(6):1407-12
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory