Ticam2^tm1Btlr
Targeted Allele Detail

Summary

• Symbol: Ticam2^tm1Btlr
• Name: TIR domain containing adaptor molecule 2; targeted mutation 1, Bruce Beutler
• MGI ID: MGI:3722129
• Synonyms: Tram^-, TRAM KO
• Gene: Ticam2 Location: Chr18:46691298-46707600 bp, - strand Genetic Position: Chr18, 24.65 cM
• Alliance: Ticam2^tm1Btlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124488
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: To generate a null allele, exon 3, which encompasses the entire coding region, was replaced with a neomycin resistance selection cassette. No transcript is detected in homozygous tissue. (J:124488)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ticam2 Mutation: 21 strains or lines available

Notes

Peritoneal macrophages from homozygous mice produce no type I interferon (IFN), and reduced amounts of tumor necrosis factor (TNF)-alpha in response to lipopolysaccharide (LPS), a Toll-like receptor (TLR) 4 ligand. Homozygous macrophages produce normal levels of type I IFN in response to poly I:C (TLR3 ligand).

References

• Original: J:124488 Georgel P, et al., Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology. 2007 Jun 5;362(2):304-13
• All: 5 reference(s)