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Traf3tm1Bshp
Targeted Allele Detail
Nomenclature
Symbol: Traf3tm1Bshp
Name: TNF receptor-associated factor 3; targeted mutation 1, Gail A Bishop
MGI ID: MGI:3722126
Synonyms: Traf3flox
Gene: Traf3  Location: Chr12:111166370-111267153 bp, + strand  Genetic Position: Chr12, 60.94 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124329
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted to flank the first two coding exons of the locus. An frt-flanked neo was included in the vector and subsequently removed by crossing with FLP deleter mice. (J:124329)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf3 Mutation:  14 strains or lines available
References
Original:  J:124329 Xie P, et al., Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. Immunity. 2007 Aug;27(2):253-67
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory