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Tg(GSK3B*S9A)1Vln
Transgene Detail
Nomenclature
Symbol: Tg(GSK3B*S9A)1Vln
Name: transgene insertion 1, Fred Fan Leuven
MGI ID: MGI:3722095
Synonyms: GSK-3B(S9A)
Transgene: Tg(GSK3B*S9A)1Vln  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(GSK3B*S9A)1Vln expresses 1 gene
 
Mutation detailsDNA coding for human GSK-3B(S9A) was ligated into a vector based on the mouse Thy1 gene and was microinjected into 0.5-day old FVB/N prenuclear mouse embryos. Expression of human GSK3B protein was demonstrated by Western blot in the brain and spinal cord of the mice. (J:100971)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:100971 Spittaels K, et al., Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. J Biol Chem. 2000 Dec 29;275(52):41340-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory