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Gabrg2tm1Wul
Targeted Allele Detail
Nomenclature
Symbol: Gabrg2tm1Wul
Name: gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2; targeted mutation 1, Peter Wulff
MGI ID: MGI:3721943
Synonyms: gamma2I77lox
Gene: Gabrg2  Location: Chr11:41910203-42000857 bp, - strand  Genetic Position: Chr11, 24.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124171
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 4 was replaced with an exon containing a phenylalanine to isoleucine mutation at position 77 (F77I). This point mutation confers drug insensitivity to zolpidem. A loxP site was inserted in the upstream intron and a frt-flanked neomycin cassette followed by another loxP site was inserted in the downstream intron. Chimeric mice were mated with a Flp deleter strain to remove the neomycin cassette. Genomic sequencing of homozygous mice confirmed the presence of the F to I mutation. (J:124171)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabrg2 Mutation:  5 strains or lines available
References
Original:  J:124171 Wulff P, et al., From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors. Nat Neurosci. 2007 Jul;10(7):923-9
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory