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Targeted Allele Detail
Symbol: Casq2tm2Jse
Name: calsequestrin 2; targeted mutation 2, Jonathan G Seidman
MGI ID: MGI:3721902
Synonyms: Casq2deltaE9
Gene: Casq2  Location: Chr3:102086415-102146514 bp, + strand  Genetic Position: Chr3, 44.3 cM, cytoband F3
Germline Transmission:  Earliest citation of germline transmission: J:124211
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA targeting construct removed exon 9 and placed a floxed neo cassette into the upstream intron. Chimeric mice were bred with Cre transgenic mice to excise the neo cassette. No protein was expressed in homozygous mice as measured by western blots of heart tissue. (J:124211)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casq2 Mutation:  17 strains or lines available
Original:  J:124211 Song L, et al., Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. J Clin Invest. 2007 Jul;117(7):1814-23
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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