Plec^tm4Gwi
Targeted Allele Detail

Summary

• Symbol: Plec^tm4Gwi
• Name: plectin; targeted mutation 4, Gerhard Wiche
• MGI ID: MGI:3721885
• Synonyms: Plec^flox
• Gene: Plec Location: Chr15:76055174-76115578 bp, - strand Genetic Position: Chr15, 35.48 cM
• Alliance: Plec^tm4Gwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124213
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A FRT-flanked neo cassette followed by a loxP site was inserted in the intron 25 of the targeted gene. An additional loxP site was added to intron 31. Mice were bred to Flpe-expressing mice to excise the neo cassette, leaving exons 26 through 31 flanked by loxP sites. (J:124213)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plec Mutation: 173 strains or lines available

References

• Original: J:124213 Ackerl R, et al., Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects. J Cell Sci. 2007 Jul 15;120(Pt 14):2435-43
• All: 9 reference(s)