About   Help   FAQ
Targeted Allele Detail
Symbol: Plectm4Gwi
Name: plectin; targeted mutation 4, Gerhard Wiche
MGI ID: MGI:3721885
Synonyms: Plecflox
Gene: Plec  Location: Chr15:76170974-76231378 bp, - strand  Genetic Position: Chr15, 35.48 cM
Germline Transmission:  Earliest citation of germline transmission: J:124213
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA FRT-flanked neo cassette followed by a loxP site was inserted in the intron 25 of the targeted gene. An additional loxP site was added to intron 31. Mice were bred to Flpe-expressing mice to excise the neo cassette, leaving exons 26 through 31 flanked by loxP sites. (J:124213)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plec Mutation:  3 strains or lines available
Original:  J:124213 Ackerl R, et al., Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects. J Cell Sci. 2007 Jul 15;120(Pt 14):2435-43
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory