Hhex^tm2Cwb
Targeted Allele Detail

Summary

• Symbol: Hhex^tm2Cwb
• Name: hematopoietically expressed homeobox; targeted mutation 2, Clifford W Bogue
• MGI ID: MGI:3721426
• Synonyms: Hhex^flox
• Gene: Hhex Location: Chr19:37423289-37429179 bp, + strand Genetic Position: Chr19, 32.28 cM, cytoband D1
• Alliance: Hhex^tm2Cwb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124126
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A FRT-flanked neo cassette followed by a loxP site was inserted in the first intron of the targeted gene. An additional loxP site was added downstream of exon 3. Mice were bred to Flpe-expressing mice to excise the neo cassette, leaving exons 2 and 3 flanked by loxP sites. (J:124126)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hhex Mutation: 16 strains or lines available

References

• Original: J:124126 Hunter MP, et al., The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Dev Biol. 2007 Aug 15;308(2):355-67
• All: 11 reference(s)