Evc^tm1Jago
Targeted Allele Detail

Summary

• Symbol: Evc^tm1Jago
• Name: EvC ciliary complex subunit 1; targeted mutation 1, Judith A Goodship
• MGI ID: MGI:3721399
• Gene: Evc Location: Chr5:37446442-37494238 bp, - strand Genetic Position: Chr5, 20.06 cM
• Alliance: Evc^tm1Jago page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124105
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first exon was replaced by a beta-galactosidase gene. LacZ recapitulates endogenous expression. No RNA or protein was detected by RT-PCR and immunofluorescent staining of the developing bones of homozygous mice. Expression of two proximal genes, Crmp1 and Evc2, were not affected. (J:124105)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Evc Mutation: 33 strains or lines available

References

• Original: J:124105 Ruiz-Perez VL, et al., Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia. Development. 2007 Aug;134(16):2903-12
• All: 5 reference(s)