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Targeted Allele Detail
Symbol: Siglec1tm1(HBEGF)Mtka
Name: sialic acid binding Ig-like lectin 1, sialoadhesin; targeted mutation 1, Masato Tanaka
MGI ID: MGI:3720841
Synonyms: CD169DTR, CD169-DTR
Gene: Siglec1  Location: Chr2:130911140-130928685 bp, - strand  Genetic Position: Chr2, 63.26 cM, cytoband F-H1
Germline Transmission:  Earliest citation of germline transmission: J:123958
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA 28-bp fragment including the endogenous ATG in exon 1 was replaced with human heparin-binding EGF-like growth factor and a floxed neo cassette. (J:123958)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Siglec1 Mutation:  58 strains or lines available
Original:  J:123958 Miyake Y, et al., Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest. 2007 Aug;117(8):2268-78
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory