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Prkcitm1Rfar
Targeted Allele Detail
Nomenclature
Symbol: Prkcitm1Rfar
Name: protein kinase C, iota; targeted mutation 1, Robert V Farese Sr
MGI ID: MGI:3720810
Synonyms: aPKClambdafl, PKClambdafl, PKClambda/iota, Prkcitm1Far, Prkcitm1Rvf
Gene: Prkci  Location: Chr3:30995747-31052959 bp, + strand  Genetic Position: Chr3, 14.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123964
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe exon containing nucleotides 110-233 (exon 2) was flanked by loxP sites. A neomycin resistance cassette was inserted downstream of the exon. (J:87746)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkci Mutation:  67 strains or lines available
References
Original:  J:123964 Farese RV, et al., Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest. 2007 Aug;117(8):2289-301
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/13/2017
MGI 6.11
The Jackson Laboratory