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Transgene Detail
Symbol: Tg(Ckm-APPSw)A2Lfa
Name: transgene insertion A2, Frank M LaFerla
MGI ID: MGI:3720795
Synonyms: A2 line, Tg(Ckm-APP*K670N*M671L)A2Lfa
Transgene: Tg(Ckm-APPSw)A2Lfa  Location: unknown  
Strain of Origin:  C57BL/6 x SJL
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Ckm-APPSw)A2Lfa expresses 1 gene
Mutation detailsHuman APP cDNA harboring the Swedish double mutation (K670N,M671L) was inserted downstream of the 1.3 kb 5' flanking sequence of the mouse muscle creatine kinase Ckm, upstream of the SV40 polyadenylation signal. The 3.8 kb construct was microinjected into pronuclei of single-cell C57Bl/6 x SJL embryos. Northern blot showed relatively low expression of the transgene in skeletal muscle of line A2 mice. (J:76338)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:76338 Sugarman MC, et al., Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6334-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory