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Tg(Ckm-APPSw)A2Lfa
Transgene Detail
Nomenclature
Symbol: Tg(Ckm-APPSw)A2Lfa
Name: transgene insertion A2, Frank M LaFerla
MGI ID: MGI:3720795
Synonyms: A2 line, Tg(Ckm-APP*K670N*M671L)A2Lfa
Transgene: Tg(Ckm-APPSw)A2Lfa  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ckm-APPSw)A2Lfa expresses 1 gene
 
Mutation detailsHuman APP cDNA harboring the Swedish double mutation (K670N,M671L) was inserted downstream of the 1.3 kb 5' flanking sequence of the mouse muscle creatine kinase Ckm, upstream of the SV40 polyadenylation signal. The 3.8 kb construct was microinjected into pronuclei of single-cell C57Bl/6 x SJL embryos. Northern blot showed relatively low expression of the transgene in skeletal muscle of line A2 mice. (J:76338)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:76338 Sugarman MC, et al., Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6334-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory