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Targeted Allele Detail
Symbol: Pdcd1lg2tm3Shr
Name: programmed cell death 1 ligand 2; targeted mutation 3, Arlene H Sharpe
MGI ID: MGI:3720328
Synonyms: PD-L1/L2-, PD-L1/PD-L2-
Gene: Pdcd1lg2  Location: Chr19:29410919-29471157 bp, + strand  Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
Germline Transmission:  Earliest citation of germline transmission: J:123785
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace the IgV exon with a hygromycin resistance gene in ES cells containing the Cd274tm1Shr allele in which the CD274 antigen signal and all of the IgV exon were replaced with a neomycin resistance gene. (J:123785)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdcd1lg2 Mutation:  8 strains or lines available
Original:  J:123785 Keir ME, et al., Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med. 2006 Apr 17;203(4):883-95
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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