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Abca2tm1Nina
Targeted Allele Detail
Nomenclature
Symbol: Abca2tm1Nina
Name: ATP-binding cassette, sub-family A (ABC1), member 2; targeted mutation 1, Nobuya Inagaki
MGI ID: MGI:3719855
Synonyms: Abca2-
Gene: Abca2  Location: Chr2:25428703-25448540 bp, + strand  Genetic Position: Chr2, 17.25 cM, cytoband A2-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123521
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 13-22 were replaced with a pgk-neo cassette. The deleted sequence encodes the Walker A motif of the nucleotide binding domain. (J:123521)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abca2 Mutation:  36 strains or lines available
References
Original:  J:123521 Sakai H, et al., ABCA2 deficiency results in abnormal sphingolipid metabolism in mouse brain. J Biol Chem. 2007 Jul 6;282(27):19692-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory