Glis2^tm1Tre
Targeted Allele Detail

Summary

• Symbol: Glis2^tm1Tre
• Name: GLIS family zinc finger 2; targeted mutation 1, Mathias Treier
• MGI ID: MGI:3719836
• Synonyms: Glis2^lacZ
• Gene: Glis2 Location: Chr16:4412577-4442788 bp, + strand Genetic Position: Chr16, 2.45 cM, cytoband A1-B1
• Alliance: Glis2^tm1Tre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123510
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 3-5 with an in-frame lacZ with the self-excisable neo cassette (ACN). (J:123510)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glis2 Mutation: 102 strains or lines available

References

• Original: J:123510 Attanasio M, et al., Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nat Genet. 2007 Aug;39(8):1018-24
• All: 1 reference(s)