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Targeted Allele Detail
Symbol: Lats2tm1Noj
Name: large tumor suppressor 2; targeted mutation 1, Hiroshi Nojima
MGI ID: MGI:3719818
Synonyms: Lats2-
Gene: Lats2  Location: Chr14:57642077-57758388 bp, - strand  Genetic Position: Chr14, 30.28 cM
Lats2tm1Noj/Lats2tm1Noj embryos exhibit severe nervous system developmental defects

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:123480
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    The entire coding region was disrupted by replacing the first coding exon with the neo cassette. (J:123480)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lats2 Mutation:  17 strains or lines available
Original:  J:123480 Yabuta N, et al., Lats2 is an essential mitotic regulator required for the coordination of cell division. J Biol Chem. 2007 Jun 29;282(26):19259-71
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory