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Ptpn6tm1Rsky
Targeted Allele Detail
Nomenclature
Symbol: Ptpn6tm1Rsky
Name: protein tyrosine phosphatase, non-receptor type 6; targeted mutation 1, Klaus Rajewsky
MGI ID: MGI:3719625
Synonyms: Ptpn6f, SHP-1Flox
Gene: Ptpn6  Location: Chr6:124720707-124738709 bp, - strand  Genetic Position: Chr6, 59.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123568
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA vector was designed to flank exon 1 through exon 9 with loxP sites. A floxed neo was removed via transient cre expression. (J:123568)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn6 Mutation:  32 strains or lines available
References
Original:  J:123568 Pao LI, et al., B cell-specific deletion of protein-tyrosine phosphatase shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity. 2007 Jul;27(1):35-48
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory