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Tgfb1tm2Flv
Targeted Allele Detail
Nomenclature
Symbol: Tgfb1tm2Flv
Name: transforming growth factor, beta 1; targeted mutation 2, Richard A Flavell
MGI ID: MGI:3719583
Synonyms: TGF-b1-GFP, Tgfb1n
Gene: Tgfb1  Location: Chr7:25687002-25705077 bp, + strand  Genetic Position: Chr7, 13.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123547
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA green-fluorescent protein was inserted into the first exon of the gene to generate a null allele. A floxed neo cassette inserted downstream of the modified exon 1 was removed by cre-mediated recombination. (J:123547)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfb1 Mutation:  23 strains or lines available
References
Original:  J:123547 Li MO, et al., T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity. 2007 May;26(5):579-91
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory