Pvr^tm1Gbn
Targeted Allele Detail

Summary

• Symbol: Pvr^tm1Gbn
• Name: poliovirus receptor; targeted mutation 1, Gunter Bernhardt
• MGI ID: MGI:3719436
• Synonyms: Cd155^-
• Gene: Pvr Location: Chr7:19637503-19655068 bp, - strand Genetic Position: Chr7, 9.95 cM, cytoband A2-B1
• Alliance: Pvr^tm1Gbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123540
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1-3 were replaced with a beta-gal-neo cassette. Flow cytometry confirmed absence of protein. (J:123540)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pvr Mutation: 34 strains or lines available

References

• Original: J:123540 Maier MK, et al., The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens. Eur J Immunol. 2007 Aug;37(8):2214-25
• All: 11 reference(s)